Selective Release of anti–TB Drugs Complex from Smart Copolymeric Bioactive nano–carriers

Continuous release of gentamicin from gold nanocarriers

Antibiotics are still the most effective agents used to fight bacterial infections. Antibiotics are quickly metabolised or excreted from the human body, thus they need to be frequently administered (a few times a day) and their half life is usually an important factor in the therapeutic choice. In order to render the administration less frequent, antibiotic release from a carrier can be employe...

NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release.

An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleava...

Book Review: Smart Pharmaceutical Nanocarriers

Sustained Release of Bioactive Compounds from Polymer Microcapsules for Smart Dental Composites

Natural plant extracts have been shown as effective and attractive dental biomaterials with promising properties for restorative/reparative procedures. These bioactive extracts, however, may lose their stability when exposed to air, moisture, or light, if not well-protected. Here, we present a novel technique for sequestering bioactive extracts within polymer microcapsules for long-term stabili...

The controlled release of dexamethasone sodium phosphate from bioactive electrospun PCL/gelatin nanofiber scaffold

In this study, a system of dexamethasone sodium phosphate (DEXP)-loaded chitosan nanoparticles embedded in poly-ε-caprolacton (PCL) and gelatin electrospun nanofiber scaffold was introduced with potential therapeutic application for treatment of the nervous system. Besides anti-inflammatory properties, DEXP act through its glucocorticoid receptors, which are involved in the inhibition of astroc...